TB vaccines; promoting rapid and durable protection in the lung.

TitleTB vaccines; promoting rapid and durable protection in the lung.
Publication TypeJournal Article
Year of Publication2015
AuthorsAndersen P, Urdahl KB
JournalCurr Opin Immunol
Volume35
Pagination55-62
Date Published2015 Aug
ISSN1879-0372
KeywordsAnimals, Clinical Trials as Topic, Humans, Immunologic Memory, Interferon-gamma, Lung, Mycobacterium tuberculosis, T-Lymphocytes, Tuberculosis, Vaccines
Abstract

TB vaccine discovery has focused on IFN-γ both for the selection of antigens and vaccine delivery strategies. Recent breakthroughs in our understanding of the requirements for immunological memory and the expression of immunity to TB in the lung now provide a framework for reconsidering that strategy. We will discuss the status of the TB vaccine field, recent insights into the role of central memory cells and the potential of tissue-resident memory cells in vaccine promoted protection against TB.

DOI10.1016/j.coi.2015.06.001
Alternate JournalCurr. Opin. Immunol.
PubMed ID26113434
PubMed Central IDPMC4641675
Grant ListR01 AI076327 / AI / NIAID NIH HHS / United States
U19 AI106761 / AI / NIAID NIH HHS / United States