TB vaccines; promoting rapid and durable protection in the lung.
|Title||TB vaccines; promoting rapid and durable protection in the lung.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Andersen P, Urdahl KB|
|Journal||Curr Opin Immunol|
|Date Published||2015 Aug|
|Keywords||Animals, Clinical Trials as Topic, Humans, Immunologic Memory, Interferon-gamma, Lung, Mycobacterium tuberculosis, T-Lymphocytes, Tuberculosis, Vaccines|
TB vaccine discovery has focused on IFN-γ both for the selection of antigens and vaccine delivery strategies. Recent breakthroughs in our understanding of the requirements for immunological memory and the expression of immunity to TB in the lung now provide a framework for reconsidering that strategy. We will discuss the status of the TB vaccine field, recent insights into the role of central memory cells and the potential of tissue-resident memory cells in vaccine promoted protection against TB.
|Alternate Journal||Curr. Opin. Immunol.|
|PubMed Central ID||PMC4641675|
|Grant List||R01 AI076327 / AI / NIAID NIH HHS / United States |
U19 AI106761 / AI / NIAID NIH HHS / United States