Tuberculosis, responsible for nearly two million deaths each year, is caused by the bacterium Mycobacterium tuberculosis (MTB). Researchers from the Institute of Systems Biology in collaboration with Seattle BioMed have undertaken a comprehensive approach centered around the strengths of systems biology to identify adaptive regulatory mechanisms employed by MTB.
In a study published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers from the Institute for Systems Biology and Seattle BioMed identified the protein phosphotyrosine post-translational modifications critical to the growth of Mycobacterium tuberculosis (Mtb), a pathogen that causes the highly infectious disease tuberculosis (TB).
It may not be marked on your calendar, but today, March 24 is World TB Day , created to remind people of the massive global health problem caused by tuberculosis. On this day in 1882, the brilliant microbiologist Dr. Robert Koch announced his stunning discovery that TB is caused by infection with a bacterium,Mycobacterium tuberculosis. At the time, TB killed one in seven people in Europe and the Americas. Now, 132 years later, TB still kills more people than any other infection save AIDS – and many AIDS patients worldwide actually die of TB. Why does TB continue to rage despite decades of scientific progress, and why am I nonetheless hopeful that great improvements in stopping TB are possible?