Omics4TB Disease Progression

This website serves as a portal for computational modeling program to generate an integrated, predictive gene regulatory network model of host/pathogen interactions by using omics data.

MTB Network Portal Host Network Portal Modeling Framework

The Omics for TB Disease Progression (OTB) program at Seattle BioMed is pleased to announce a call for proposals for our Pilot Research Projects initiative in the coming year.  This program is an extension of our parent award from NIH/NIAID and provides an exciting opportunity to explore high-risk, innovative approaches related to tuberculosis research.


Tuberculosis, responsible for nearly two million deaths each year, is caused by the bacterium Mycobacterium tuberculosis (MTB). Researchers from the Institute of Systems Biology in collaboration with Seattle BioMed have undertaken a comprehensive approach centered around the strengths of systems biology to identify adaptive regulatory mechanisms employed by MTB.

In a study published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers from the Institute for Systems Biology and Seattle BioMed identified the protein phosphotyrosine post-translational modifications critical to the growth of Mycobacterium tuberculosis (Mtb), a pathogen that causes the highly infectious disease tuberculosis (TB). 

Source: ISB Molecular Me