Blood RNA signatures prospectively discriminate controllers from progressors early after low-dose M. tuberculosis infection of cynomolgus macaques

TitleBlood RNA signatures prospectively discriminate controllers from progressors early after low-dose M. tuberculosis infection of cynomolgus macaques
Publication TypeJournal Article
Year of Publication2018
AuthorsThompson EG, Shankar S, Gideon HP, Braun J, Valvo J, Skinner J, Aderem A, Flynn JAL, Lin PLing, Zak DE
Paginationjiy006 - jiy006
Date Published2018/01/08
ISBN Number0022-1899
Abstract

The cynomolgus macaque model of low-dose Mycobacterium tuberculosis (Mtb) infection recapitulates clinical aspects of human TB pathology but it is unknown whether the two systems are sufficiently similar that host-based signatures of TB will be predictive across species. By blind prediction, we demonstrate that a subset of genes comprising a human signature for TB risk is simultaneously predictive in humans and macaques and prospectively discriminates progressor from controller animals 3-6 weeks after infection. Further analysis yielded a 3-gene signature involving PRDX2 that predicts TB progression in macaques 10 days after challenge, suggesting novel pathways that define protective responses to Mtb.

URLhttp://dx.doi.org/10.1093/infdis/jiy006
Short TitleThe Journal of Infectious Diseases