Blood RNA signatures prospectively discriminate controllers from progressors early after low-dose M. tuberculosis infection of cynomolgus macaques
|Title||Blood RNA signatures prospectively discriminate controllers from progressors early after low-dose M. tuberculosis infection of cynomolgus macaques|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Thompson EG, Shankar S, Gideon HP, Braun J, Valvo J, Skinner J, Aderem A, Flynn JAL, Lin PLing, Zak DE|
|Pagination||jiy006 - jiy006|
The cynomolgus macaque model of low-dose Mycobacterium tuberculosis (Mtb) infection recapitulates clinical aspects of human TB pathology but it is unknown whether the two systems are sufficiently similar that host-based signatures of TB will be predictive across species. By blind prediction, we demonstrate that a subset of genes comprising a human signature for TB risk is simultaneously predictive in humans and macaques and prospectively discriminates progressor from controller animals 3-6 weeks after infection. Further analysis yielded a 3-gene signature involving PRDX2 that predicts TB progression in macaques 10 days after challenge, suggesting novel pathways that define protective responses to Mtb.
|Short Title||The Journal of Infectious Diseases|